The following list is merely illustrative of the aims and scope of the journal; other topics may be suitable.
Data management
Trial logistics
Statistical methods
Statistical methods for analyzing and designing all types of clinical
trials
Methods to handle departures from randomization
Quality of life assessment
Use of economic outcomes
Methods for handling missing data
Sample size calculations for specific design features
Methods for diagnostic tests
Design and conduct
Interesting design features of specific trials ("Design" papers)
Organizational aspects of multicenter investigations
Data and safety monitoring
Assessing patient adherence
Design of case report forms and other data collection methods
Methods for collecting and reporting adverse event data
Procedures for maintaining databases.
Informatics
Quality assurance procedures
Data auditing
Impact
The impact of clinical trials on the practice of medicine or subsequent
research
Role of clinical trials in health policy
Ethics
Empirical ethics research
Informed consent
Ethics of international or trans-cultural clinical trials
Ethics of recruitment
Law and regulation
Harmonization
Issues in drug or device development
Synthesis and evidence evaluation
Assessment of the quality of clinical trials
Comparisons of clinical trials and alternative research methodologies
Methodology of evidence synthesis, meta-analysis, systematic reviews
Issues related to the reporting, publication or peer review of clinical
trials
History
Historical reviews of important trials or syntheses
Interviews with senior investigators of landmark trials
Education and training
Methods for education and training in clinical trial methods
Tutorials on any methods related to clinical trial conduct or analysis
Patient-related issues
Patient involvement in the design or monitoring of clinical trials
Assessing patient preferences
Communicating clinical trial results to patients and lay audiences
Working with and educating advocacy groups about clinical trials
Representation of subgroups in clinical trials
Miscellany
Decision analysis, Cost-benefit analysis as they relate to trials
Commentaries on recent debates or issues in clinical trials
